CASE REPORT: LONGITUDINAL MONITORING OF CLONAL EVOLUTION BY CIRCULATING TUMOR DNA FOR RESISTANCE TO ANTI-EGFR ANTIBODY IN A CASE OF METASTATIC COLORECTAL CANCER

BackgroundTreatment with anti-EGFR antibody has been shown to prolong survival in patients with RAS wild-type metastatic colorectal cancer (mCRC).However, even patients who initially respond to anti-EGFR antibody therapy, almost without exception, develop resistance to the therapy and then fail to respond.Secondary mutations in the mitogen-activate

Abstract Backgrounds Glomerular diseases, a set of debilitating and complex disease entities, are related to mortality and morbidity.To gain insight into pathophysiology and novel treatment targets of glomerular disease, various types of biospecimens linked to deep clinical phenotyping including clinical information, digital pathology, and well-def

Today, a brand new strategy that can foster agricultural production is being shaped based on IT solutions.The paper characterizes the state and prospects for the development of digital farm management, the challenges of mastering digital innovations by agricultural enterprises and ways to tackle them at the present stage.A study is relevant due to

In response to stress and injury a coordinated activation of conserved signalling modules, such as JNK and JAK/STAT, is critical to trigger regenerative tissue restoration.While these pathways rebuild homeostasis and promote faithful organ recovery, it is intriguing that they also become activated in various tumour conditions.Therefore, it is Foam

Association analysis has been proven as a powerful tool Foam Plates/Bowls for the genetic dissection of complex traits.This study was conducted to identify association of recovery, persistence, and summer dormancy with sequence related amplified polymorphism (SRAP) markers in 36 smooth bromegrass genotypes under two moisture conditions and find sta